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Big Journals publication

Contributor: Kseniia Eruslanova

Origin/Afiliation: Kseniia Eruslanova, MD, MSc. Russian clinical and research geriatric center

Recently top-rated journals published a few papers related to geriatric medicine.

First of all, European Heart Journal published the results of the National Health and Aging Trends Study: 4 565 patients with frailty (assed by Fried score) without CAD had a higher risk of development MACE (death, myocardial infarction, peripheral vascular disease, and coronary artery diseases. In general, people with frailty were older. However, when were perform an adjusted analysis, including age, gender, BMI, smoking status, hypertension, diabetes, and other well-known risk factors, frailty still was an independent risk factor. In conclusion, the authors highlight that: "frailty assessment as part of primary cardiovascular prevention programs in older adults at risk for cardiovascular disease are essential in daily clinical cardiovascular practice".

Moreover, Lancet published a systemic review: "Oral frailty and its determinants in older ade". They used 39 papers for analysis and make an attempt to systemize the oral problem in 4 categories: oral health status deterioration; deterioration of oral motor skills; chewing, swallowing, and saliva disorders, and oral pain. A review in detail discussed the connection between oral health and frailty. Poor oral health can be a possible predictor of frailty. In an ideal world, routine oral health assessment should be performed in a gerodontologic setting. However, it is not always possible. And simple tooth count can be a good marker for general health.

Last but not least, is a Nature Aging publication: what is an inflammatory aging clock (iAge)?

For the last decades, numerous studies showed that sustained systemic inflammation is linked to 9 hallmarks of aging: (1) genomic instability, (2) shortening telomere length, (3) epigenetic modifications, (4) loss of proteostasis, (5) deregulated nutrient sensing, (6) mitochondrial dysfunction, (7) cellular senescence, (8) stem cell exhaustion and (9) altered intracellular communication. The authors of the study, based on the analysis of 1000 blood samples, present "inflammatory clocks of aging." They can be used to predict multimorbidity and mortality and can be used as a biological surrogate of age-related health versus disease. In addition, during the study, researchers estimated and the critical role of CXCL9 in inflammatory aging and marked it as possible future target slowing aging processes.



1. Abdulla A Damluji, Shang-En Chung, Qian-Li Xue, Rani K Hasan, Mauro Moscucci, Daniel E Forman, Karen Bandeen-Roche, Wayne Batchelor, Jeremy D Walston, Jon R Resar, Gary Gerstenblith, Frailty and cardiovascular outcomes in the National Health and Aging Trends Study, European Heart Journal, 2021;, ehab468,

2. Vittorio Dibello, Roberta Zupo, Rodolfo Sardone, Madia Lozupone, Fabio Castellana, Antonio Dibello, Antonio Daniele, Giovanni De Pergola, Ilaria Bortone, Luisa Lampignano, Gianluigi Giannelli, Francesco Panza. Oral frailty and its determinants in older age: a systematic review,

The Lancet Healthy Longevity, Volume 2, Issue 8, 2021, Pages e507-e520, ISSN 2666-7568,

3. Sayed, N., Huang, Y., Nguyen, K. et al. An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nat Aging 1, 598–615 (2021).

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1 comentário

26 de ago. de 2021

Excellent blog and very interesting studies! Thank you very much for pointing them out for us all !

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